concept

PROTEIN AGGREGATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROTEIN AGGREGATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

658Connections

0Hypotheses

6Analyses

50Outgoing

50Incoming

0Experiments

Summary

PROTEIN AGGREGATION is a concept in neurodegeneration research. Key relationships include: associated with, co discussed, regulates. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 49 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	PROTEIN AGGREGATION
Summary	Page for Protein Aggregation and Misfolding in Neurodegeneration
Key Genes/Proteins	TREM2, TFEB
Related Diseases	NEUROINFLAMMATION, CHOLESTEROL, MITOPHAGY, SENESCENCE, INFLAMMATION

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PROTEIN_AGGREGATION["PROTEIN AGGREGATION"]
    PROTEIN_AGGREGATION -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    PROTEIN_AGGREGATION -->|"activates"| Neuroinflammation["Neuroinflammation"]
    Autophagy_lysosomal_pathway["Autophagy-lysosomal pathway"] -.protects against.-> PROTEIN_AGGREGATION
    autophagy_lysosomal_pathway["autophagy-lysosomal pathway"] -.protects against.-> PROTEIN_AGGREGATION
    autophagy["autophagy"] -.protects against.-> PROTEIN_AGGREGATION
    Neuroinflammation -->|"activates"| PROTEIN_AGGREGATION
    CERS2["CERS2"] -->|"inhibits"| PROTEIN_AGGREGATION
    CHMP2A["CHMP2A"] -->|"activates"| PROTEIN_AGGREGATION
    CHMP2B["CHMP2B"] -->|"activates"| PROTEIN_AGGREGATION
    CHMP6["CHMP6"] -->|"activates"| PROTEIN_AGGREGATION
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| PROTEIN_AGGREGATION
    PTN["PTN"] -->|"expressed in"| PROTEIN_AGGREGATION

Outgoing (91)

Target	Relation	Type	Str
neurodegeneration	causes	process	0.95
Alzheimer's Disease	causes	disease	0.95
Neurodegenerative Diseases	causes	disease	0.95
Amyloid	associated_with	protein	0.95
neurodegenerative diseases	contributes_to	disease	0.95
Neurodegeneration	associated_with	disease	0.95
Neurodegenerative Diseases	contributes_to	disease	0.92
Huntington's Disease	causes	disease	0.90
neurodegeneration	mediates	phenotype	0.90
Amyloid-Beta	involved_in	protein	0.90
Tau	involved_in	protein	0.90
Neuroinflammation	causes	process	0.90
SOLUBLE OLIGOMERS	associated_with	protein	0.90
Neuroplasticity	associated_with	process	0.90
Neurodegenerative Diseases	associated_with	disease	0.90
Neurodegenerative Disease	causes	disease	0.90
Alzheimer's Disease	mediates	disease	0.90
Alzheimer's Disease	contributes_to	disease	0.90
Neuronal Degeneration	contributes_to	process	0.90
Parkinson's Disease	causes	disease	0.90
Alzheimer's Disease	causes	disease	0.90
detergent-insoluble proteome	contributes_to	process	0.85
Alzheimer's Disease	contributes_to	disease	0.85
Neurodegeneration	contributes_to	disease	0.85
ALZHEIMER'S DISEASE	causes	disease	0.85
Neurodegeneration	causes	process	0.85
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.85
pathological spreading	causes (protein aggregation drives cell-to-cell spreading )	mechanism	0.85
geographic atrophy	promotes	phenotype	0.80
Amyotrophic Lateral Sclerosis	causes	disease	0.75
neuronal loss	promotes	process	0.70
Alzheimer's disease	causes	disease	0.70
Neuroinflammation	activates	process	0.70
inflammation	promotes	process	0.70
Er Stress	activates	pathway	0.70
Mitochondrial Dysfunction	causes	mechanism	0.70
Transcriptional Dysregulation	causes	mechanism	0.70
SENESCENCE	interacts_with	phenotype	0.65
SNCA	activates	gene	0.60
PROTEOSTASIS	targets	phenotype	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	process	0.50
MITOCHONDRIAL DYSFUNCTION	activates	process	0.50
ALZHEIMER'S	expressed_in	concept	0.50
AMYLOID-β	expressed_in	concept	0.50
ALZHEIMER'S	associated_with	concept	0.50
FRONTOTEMPORAL	associated_with	concept	0.50
Proteostasis	associated_with	process	0.50
Protein Folding	associated_with	pathway	0.50
ENDOPLASMIC RETICULUM	associated_with	concept	0.50
PARKINSON'S	activates	concept	0.50

Incoming (567)

Source	Relation	Type	Str
RNA G-quadruplexes	mediates	process	0.95
Tardbp	promotes	protein	0.92
HNRNPA2B1	contributes_to	protein	0.92
SQSTM1	regulates	gene	0.90
HTT	promotes	gene	0.90
amyloid-beta peptide	promotes	compound	0.90
tau	promotes	protein	0.90
HSP90	suppresses	protein	0.90
phase separation	drives	process	0.90
Neuroinflammation	upregulates	process	0.90
Autophagy	associated_with	process	0.90
Proteostasis Disruption	causes	process	0.90
Neurodegeneration-Associated Proteins Accumulation	promotes	phenotype	0.90
SNCA	involved_in	protein	0.90
Amyloid-Beta	involved_in	protein	0.90
TAU	involved_in	protein	0.90
Parkin	regulates	protein	0.90
TARDBP	involved_in	protein	0.90
Intra-Condensate Demixing	mediates	process	0.90
DNAJB6	inhibits	protein	0.90
Tdp-43	drives	protein	0.90
Intrinsically Disordered Low-Complexity Domain	contributes_to	mechanism	0.90
Molecular Chaperones	suppresses	protein	0.90
PRKAA2	regulates	gene	0.90
Inflammasome	associated_with	pathway	0.88
HSPB8	modulates	protein	0.88
SQSTM1	prevents	protein	0.87
P62	biomarker_for	protein	0.85
HSPB8 FRAMESHIFT MUTANT	contributes_to	protein	0.85
intrinsically disordered domain	promotes	phenotype	0.85
chaperone-mediated autophagy	suppresses	process	0.85
protein over-synthesis	promotes	process	0.85
HSP27	suppresses	protein	0.85
super-resolution microscopy	involved_in	process	0.85
protein oligomers	involved_in	protein	0.85
Tardbp	drives	protein	0.85
Endoplasmic Reticulum Dysfunction	contributes_to	process	0.85
Proteostasis Network	regulates	pathway	0.85
Environmental Stress	promotes	process	0.85
LGMDD1	associated_with	disease	0.85
Cytoskeletal Disruption	promotes	process	0.85
Protein Clearance Enhancement	suppresses	pathway	0.85
Autophagy	suppresses	process	0.85
chromium	promotes	compound	0.80
stress granule dynamics	contributes_to	process	0.80
HUNTINGTON	implicated_in	disease	0.80
APOE	modulates	protein	0.80
METFORMIN	inhibits	drug	0.80
Protein Misfolding	causes	mechanism	0.80
Huntingtin	causes	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (6)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PROTEIN AGGREGATION

Understanding Entity Pages

Summary

Wiki Pages (21)